Synthesis of taxoids 3.: A novel and efficient method for preparation of taxoids by employing cis-glycidic acid.

被引：25

作者：

Yamaguchi, T ^{[1
]}

Harada, N ^{[1
]}

Ozaki, K ^{[1
]}

Hashiyama, T ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Med Chem Res Lab, Toda, Saitama 3358505, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 31期

关键词：

taxoids; stereocontrol; epoxides; esterification;

D O I：

10.1016/S0040-4039(98)01124-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route for the synthesis of docetaxel (2) using esterification of (2R,3R)glycidic acid with 7, 10-bis-O-(2,2,2-trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Subsequent stereo- and regio-selective conversion afforded 2 and related novel compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5575 / 5578

页数：4

共 25 条

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