Au-Fe3O4 dumbbell nanoparticles as dual-functional probes

被引：446

作者：

Xu, Chenjie ^{[1
]}

Xie, Jin

Ho, Don ^{[2
]}

Wang, Chao ^{[1
]}

Kohler, Nathan ^{[1
]}

Walsh, Edward G. ^{[3
]}

Morgan, Jeffrey R. ^{[2
]}

Chin, Y. Eugene ^{[4
]}

Sun, Shouheng ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

[2] Brown Univ, Ctr Biomed Engn, Providence, RI 02912 USA

[3] Brown Univ, Dept Neurosci, Providence, RI 02912 USA

[4] Brown Univ, Sch Med, Dept Surg, Providence, RI 02903 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 01期

关键词：

antibodies; magnetic properties; magnetic resonance imaging; nanoparticles; reflection imaging;

D O I：

10.1002/anie.200704392

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Heavy lifting: Dumbbell-shaped Au-Fe 3O4 nanoparticles are made biocompatible and suitable for attachment to A431 cells. The particles are magnetically and optically active and are useful for simultaneous magnetic and optical detection (see picture). The Au-Fe3O4 nanoparticles are promising as a new type of multifunctional probe for diagnostic and therapeutic applications. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：173 / 176

页数：4

相关论文

共 24 条

[1] Monoclonal antibody therapy of cancer [J].

Adams, GP ;

Weiner, LM .

NATURE BIOTECHNOLOGY, 2005, 23 (09) :1147-1157

[2] Biocompatible heterostructured nanoparticles for multimodal biological detection [J].

Choi, Jin-sil ;

Jun, Young-wook ;

Yeon, Soo-In ;

Kim, Hyoung Chan ;

Shin, Jeon-Soo ;

Cheon, Jinwoo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (50) :15982-15983

[3] Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer [J].

El-Sayed, IH ;

Huang, XH ;

El-Sayed, MA .

NANO LETTERS, 2005, 5 (05) :829-834

[4] Janus particles at liquid-liquid interfaces [J].

Glaser, Nicole ;

Adams, Dave J. ;

Boeker, Alexander ;

Krausch, Georg .

LANGMUIR, 2006, 22 (12) :5227-5229

[5] Heterodimers of nanoparticles: Formation at a liquid-liquid interface and particle-specific surface modification by functional molecules [J].

Gu, HW ;

Yang, ZM ;

Gao, JH ;

Chang, CK ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) :34-35

[6] Facile one-pot synthesis of bifunctional heterodimers of nanoparticles: A conjugate of quantum dot and magnetic nanoparticles [J].

Gu, HW ;

Zheng, RK ;

Zhang, XX ;

Xu, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (18) :5664-5665

[7] Recent advances on surface engineering of magnetic iron oxide nanoparticles and their biomedical applications [J].

Gupta, Ajay Kumar ;

Naregalkar, Rohan R. ;

Vaidya, Vikas Deep ;

Gupta, Mona .

NANOMEDICINE, 2007, 2 (01) :23-39

[8] VISUALIZATION BY FLUORESCENCE OF BINDING AND INTERNALIZATION OF EPIDERMAL GROWTH-FACTOR IN HUMAN CARCINOMA CELLS A-431 [J].

HAIGLER, H ;

ASH, JF ;

SINGER, SJ ;

COHEN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (07) :3317-3321

[9] Gold as a novel catalyst in the 21st century: Preparation, working mechanism and applications [J].

Haruta, M .

GOLD BULLETIN, 2004, 37 (1-2) :27-36

[10] Review of epidermal growth factor receptor biology [J].

Herbst, RS .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2004, 59 (02) :21-26