Metabolic rate in the right amygdala predicts negative affect in depressed patients

被引：257

作者：

Abercrombie, HC

Schaefer, SM

Larson, CL

Oakes, TR

Lindgren, KA

Holden, JE

Perlman, SB

Turski, PA

Krahn, DD

Benca, RM

Davidson, RJ

机构：

[1] Univ Wisconsin, Dept Psychiat, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA

[3] Univ Wisconsin, Dept Phys Med, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Nucl Med, Madison, WI 53706 USA

[5] Univ Wisconsin, Dept Neurol, Madison, WI 53706 USA

来源：

NEUROREPORT | 1998年 / 9卷 / 14期

关键词：

affect; affective disorders; affective symptoms; amygdaloid body; brain metabolism; depressive disorder; emotions; psychophysiology; tomography; emission-computed; thalamus;

D O I：

10.1097/00001756-199810050-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMR(glu)) was measured with [F-18]fluorodeoxyglucose positron emission tomography (PET) in two samples of subjects using two different PET cameras. The samples consisted of 10 and 17 medication-free depressives and 11 and 13 controls, respectively. Using coregistration of PET and magnetic resonance images, regions were individually delineated for the amygdala and thalamus, the latter of which was used as a control region. Within the depressed groups, right amygdalar rCMR(glu). was positively correlated with negative affect. Thalamic rCM(glu) was not related to negative affect, and amygdalar rCMR(glu) accounted for a significant portion variance in depressives' negative affect scores over and above the contribution of thalamic rCMR(glu). (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3301 / 3307

页数：7

共 24 条

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