Synthesis of Unsymmetrically Substituted Bipyridines by Palladium-Catalyzed Direct C-H Arylation of Pyridine N-Oxides

被引：82

作者：

Duric, Sasa ^{[1
]}

Tzschucke, C. Christoph ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 09期

关键词：

CROSS-COUPLING REACTIONS; BOND FORMATION; BORONIC ACIDS; AZINE; ARYL; 2,2'-BIPYRIDINES; 2-PYRIDYL; FUNCTIONALIZATION; CONSTRUCTION; COMPLEXES;

D O I：

10.1021/ol200565u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Substituted bipyridines were efficiently prepared by direct coupling between pyridine N-oxides and halopyridines using a palladium catalyst. Pyridine N-oxides with electron-withdrawing substitutents gave the best yields. This method allows the convenient preparation of 2,2'-, 2,3'-, and 2,4'-bipyridines which are useful as functionalized ligands for metal complexes or as building blocks for supramolecular architectures.

引用

页码：2310 / 2313

页数：4

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