Direct Arylation of Imidazo[1,2-a]pyridine at C-3 with Aryl Iodides, Bromides, and Triflates via Copper(I)-Catalyzed C-H Bond Functionalization

被引：162

作者：

Cao, Hua ^{[1
]}

Zhan, Haiying ^{[1
]}

Lin, Yuanguang ^{[1
]}

Lin, Xiulian ^{[1
]}

Du, Zuodong ^{[1
]}

Jiang, Huanfeng ^{[2
]}

机构：

[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

[2] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 07期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED ARYLATION; MEDIATED DIRECT ARYLATION; COUPLING REACTIONS; GENERAL-METHOD; PALLADIUM; ACTIVATION; HETEROARENES; HETEROCYCLES; DERIVATIVES; AZOLES;

D O I：

10.1021/ol300232a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient method for the copper(I)-catalyzed arylation of substituted imidazo[1,2-a]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo[1,2-a]pyridine by Cu(I) catalysis to construct various functionalized imidazo[1,2-a]pyridine core pi-systems.

引用

页码：1688 / 1691

页数：4

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