The NKG2D receptor: immunobiology and clinical implications

被引：83

作者：

Burgess, Steven J. ^{[1
]}

Maasho, Kerima ^{[1
]}

Masilamani, Madhan ^{[1
]}

Narayanan, Sriram ^{[1
]}

Borrego, Francisco ^{[1
]}

Coligan, John E. ^{[1
]}

机构：

[1] NIAID, Cell Biol Sect, Immunogenet Lab, Natl Inst Hlth, Rockville, MD 20852 USA

来源：

IMMUNOLOGIC RESEARCH | 2008年 / 40卷 / 01期

关键词：

natural killer cells; T cells; activating receptor; DAP10;

D O I：

10.1007/s12026-007-0060-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.

引用

页码：18 / 34

页数：17

共 113 条

[1] Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors [J].

André, P ;

Castriconi, R ;

Espéli, M ;

Anfossi, N ;

Juarez, T ;

Hue, S ;

Conway, H ;

Romagné, F ;

Dondero, A ;

Nanni, M ;

Caillat-Zucman, S ;

Raulet, DH ;

Bottino, C ;

Vivier, E ;

Moretta, A ;

Paul, P .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2004, 34 (04) :961-971

[2] Nucleotide sequence of the human MHC class I MICA gene [J].

Bahram, S ;

Mizuki, N ;

Inoko, H ;

Spies, T .

IMMUNOGENETICS, 1996, 44 (01) :80-81

[3]

Bahram S, 2000, Adv Immunol, V76, P1

[4] Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA [J].

Bauer, Stefan ;

Groh, Veronika ;

Wu, Jun ;

Steinle, Alexander ;

Phillips, Joseph H. ;

Lanier, Lewis L. ;

Spies, Thomas .

JOURNAL OF IMMUNOLOGY, 2018, 200 (07) :2231-2233

[5] NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway [J].

Billadeau, DD ;

Upshaw, JL ;

Schoon, RA ;

Dick, CJ ;

Leibson, PJ .

NATURE IMMUNOLOGY, 2003, 4 (06) :557-564

[6] Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion [J].

Bryceson, YT ;

March, ME ;

Ljunggren, HG ;

Long, EO .

BLOOD, 2006, 107 (01) :159-166

[7] Herpesviral Fcγ receptors:: culprits attenuating antiviral IgG? [J].

Budt, M ;

Reinhard, H ;

Bigl, A ;

Hengel, H .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2004, 4 (09) :1135-1148

[8] IL-21 down-regulates NKG2D/DAP10 express on human NK and CD8+ T cells [J].

Burgess, SJ ;

Marusina, AI ;

Pathmanathan, I ;

Borrego, F ;

Coligan, JE .

JOURNAL OF IMMUNOLOGY, 2006, 176 (03) :1490-1497

[9] Vav proteins, adaptors and cell signaling [J].

Bustelo, XR .

ONCOGENE, 2001, 20 (44) :6372-6381

[10] How NKG2D ligands trigger autoimmunity? [J].

Caillat-Zucman, Sophie .

HUMAN IMMUNOLOGY, 2006, 67 (03) :204-207

← 1 2 3 4 5 6 7 8 9 10 →