The NKG2D receptor: immunobiology and clinical implications

被引：83

作者：

Burgess, Steven J. ^{[1
]}

Maasho, Kerima ^{[1
]}

Masilamani, Madhan ^{[1
]}

Narayanan, Sriram ^{[1
]}

Borrego, Francisco ^{[1
]}

Coligan, John E. ^{[1
]}

机构：

[1] NIAID, Cell Biol Sect, Immunogenet Lab, Natl Inst Hlth, Rockville, MD 20852 USA

来源：

IMMUNOLOGIC RESEARCH | 2008年 / 40卷 / 01期

关键词：

natural killer cells; T cells; activating receptor; DAP10;

D O I：

10.1007/s12026-007-0060-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.

引用

页码：18 / 34

页数：17

共 113 条

[51] Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients [J].

Hughes, EH ;

Collins, RWM ;

Kondeatis, E ;

Wallace, GR ;

Graham, EM ;

Vaughan, RW ;

Stanford, MR .

TISSUE ANTIGENS, 2005, 66 (03) :195-199

[52] The role of the NKG2D immunoreceptor in immune cell activation and natural killing [J].

Jamieson, AM ;

Diefenbach, A ;

McMahon, CW ;

Xiong, N ;

Carlyle, JR ;

Raulet, DH .

IMMUNITY, 2002, 17 (01) :19-29

[53]

JAN CN, 2003, BIOCHEM BIOPH RES CO, V305, P129

[54] Therapy-induced antibodies to MHC class I chain-related protein A antagonize immune suppression and stimulate antitumor cytotoxicity [J].

Jinushi, Masahisa ;

Hodi, F. Stephen ;

Dranoff, Glenn .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (24) :9190-9195

[55] NK cell activation through the NKG2D ligand MULT-1 is selectively prevented by the glycoprotein encoded by mouse cytomegalovirus gene m145 [J].

Krmpotic, A ;

Hasan, M ;

Loewendorf, A ;

Saulig, T ;

Halenius, A ;

Lenac, T ;

Polic, B ;

Bubic, I ;

Kriegeskorte, A ;

Pernjak-Pugel, E ;

Messerle, M ;

Hengel, H ;

Busch, DH ;

Koszinowski, UH ;

Jonjic, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (02) :211-220

[56] MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo [J].

Krmpotic, A ;

Busch, DH ;

Bubic, I ;

Gebhardt, F ;

Hengel, H ;

Hasan, M ;

Scalzo, AA ;

Koszinowski, UH ;

Jonjic, S .

NATURE IMMUNOLOGY, 2002, 3 (06) :529-535

[57]

Kubin M, 2001, EUR J IMMUNOL, V31, P1428, DOI 10.1002/1521-4141(200105)31:5<1428::AID-IMMU1428>3.0.CO

[58]

2-4

[59]

Lazetic S, 1996, J IMMUNOL, V157, P4741

[60] Elevated TGF-β1 secretion and down-modulation of NKG2D underlies impaired NK cytotoxicity in cancer patients [J].

Lee, JC ;

Lee, KM ;

Kim, DW ;

Heo, DS .

JOURNAL OF IMMUNOLOGY, 2004, 172 (12) :7335-7340

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