In vivo magnetic resonance spectroscopy measurement of gray-matter and white-matter gamma-aminobutyric acid concentration in sensorimotor cortex using a motion-controlled MEGA point-resolved spectroscopy sequence

被引：36

作者：

Bhattacharyya, Pallab K. ^{[1
]}

Phillips, Micheal D. ^{[1
]}

Stone, Lael A. ^{[2
]}

Lowe, Mark J. ^{[1
]}

机构：

[1] Cleveland Clin, Imaging Inst, Cleveland, OH 44195 USA

[2] Cleveland Clin, Neurol Inst, Cleveland, OH 44195 USA

来源：

MAGNETIC RESONANCE IMAGING | 2011年 / 29卷 / 03期

基金：

美国国家卫生研究院;

关键词：

GABA; MRS; Sensorimotor cortex; Gray matter; White matter; HUMAN CEREBRAL GABA; HUMAN BRAIN; RAPID MODULATION; AMINO-ACIDS; WATER; QUANTIFICATION; SUPPRESSION; PLASTICITY; AREAS;

D O I：

10.1016/j.mri.2010.10.009

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the brain. Understanding the GABA concentration, in vivo, is important to understand normal brain function. Using MEGA point-resolved spectroscopy sequence with interleaved water scans to detect subject motion, GABA level of sensorimotor cortex was measured using a voxel identified from a functional magnetic resonance imaging scan. The GABA level in a 20x20x20-mm(3) voxel consisting of 37%+/- 7% gray matter, 52%+/- 12% white matter and 11%+/- 8% cerebrospinal fluid in the sensorimotor region was measured to be 1.43 +/- 0.48 mM. In addition, using linear regression analysis, GABA concentrations within gray and white matter were calculated to be 2.87 +/- 0.61 and 0.33 +/- 0.11 mM, respectively. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：374 / 379

页数：6

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