Transcriptional regulation of the p53 tumor suppressor gene

被引：53

作者：

Reisman, D ^{[1
]}

Loging, WT ^{[1
]}

机构：

[1] Univ S Carolina, Dept Sci Biol, Columbia, SC 29208 USA

来源：

SEMINARS IN CANCER BIOLOGY | 1998年 / 8卷 / 05期

关键词：

p53; tumor suppressor; promoter; gene expression; cancer;

D O I：

10.1006/scbi.1998.0094

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transcriptional regulation of the p53 gene plays tan important role in expression of wild type p53 and ii;! elevated expression of mutant p53 genes in tumor cells. In addition, alterations in P53 transcription levels occur in response to changes in the cell cycle. The following review describes current knowledge regarding the structures of both the human and murine p53 transcriptional regulatory regions and the factors that have been demonstrated to regulate promoter activity. The potential role of defects in transcriptional regulation of the p53 gene in oncogenic transformation is discussed.

引用

页码：317 / 324

页数：8

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