Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

被引：20

作者：

Cheng, XM ^{[1
]}

Lee, C ^{[1
]}

Klutchko, S ^{[1
]}

Winters, T ^{[1
]}

Reynolds, EE ^{[1
]}

Welch, KM ^{[1
]}

Flynn, MA ^{[1
]}

Doherty, AM ^{[1
]}

机构：

[1] WARNER LAMBERT PARKE DAVIS,PARKE DAVIS RES DIV,DEPT CARDIOVASC THERAPEUT,ANN ARBOR,MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00551-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Screening of a compound library against endothelin receptors (ET(A) and ET(B)) revealed PD 102566 (compound 1) as an ET(A) selective antagonist. Synthesis,and structure-activity relationships (SAR) of a series of analogs are described. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2999 / 3002

页数：4

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