Acute pulmonary toxicity of acrolein in rats underlying mechanism

被引：16

作者：

Arumugam, N ^{[1
]}

Sivakumar, V

Thanislass, J

Pillai, KS

Devaraj, SN

Devaraj, H

机构：

[1] Dept Zool, Biochem Unit, Chennai 600025, India

[2] Univ Madras, Dept Biochem, Chennai 600025, India

[3] Frederick Inst Plant Protect, Dept Toxicol, Padappai 601301, India

来源：

TOXICOLOGY LETTERS | 1999年 / 104卷 / 03期

关键词：

acrolein; antioxidant enzymes; lipid peroxidation; lung;

D O I：

10.1016/S0378-4274(98)00370-1

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Acute exposure of rats to acrolein (1 or 2 ppm) resulted in reduced levels of glutathione, ascorbic acid and alpha-tocopherol. The activities of catalase and glutathione peroxidase were reduced whereas an increase in the activities of superoxide dismutase was observed. This led to enhanced lipid peroxidation, which produced extensive lung damage as indicated by the elevated levels of the biochemical markers-angiotensin converting enzyme, lactate dehydrogenase, protein and lactate in the bronchoalveolar lavage. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：189 / 194

页数：6