Novel dithiocarbamate carbapenems with anti-MRSA activity

被引：26

作者：

Ohtake, N ^{[1
]}

Imamura, H ^{[1
]}

Jona, H ^{[1
]}

Kiyonaga, H ^{[1
]}

Shimizu, A ^{[1
]}

Moriya, M ^{[1
]}

Sato, H ^{[1
]}

Nakano, M ^{[1
]}

Ushijima, R ^{[1
]}

Nakagawa, S ^{[1
]}

机构：

[1] Banyu Pharmaceut Co Ltd, Tsukuba Res Inst, Tsukuba, Ibaraki 3002611, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1998年 / 6卷 / 07期

关键词：

D O I：

10.1016/S0968-0896(98)00069-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new series of 1 beta-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antibacterial activity against high-level MRSA, and the finding of good affinity for PBP-2' supported these results. Some of the compounds having favorable protein-binding affinity showed excellent in vivo anti-MRSA activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1089 / 1101

页数：13

共 19 条

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