Bacillus subtifis:: A shocking message from a Probiotic

被引：29

作者：

Williams, Paul ^{[1
]}

机构：

[1] Univ Nottingham, Inst Infect Immun & Inflammat, Ctr Biomol Sci, Nottingham NG7 2RD, England

来源：

CELL HOST & MICROBE | 2007年 / 1卷 / 04期

关键词：

D O I：

10.1016/j.chom.2007.05.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

How probiotics such as Bacillus subtilis exert a protective effect has been much debated. In this issue of Cell Host & Microbe, Fujiya et al. reveal that a B. subtilis quorum-sensing signal molecule, the competence- and sporulation-stimulating factor (CSF), is internalized via the mammalian oligopeptide transporter OCTN2, where it induces the heat shock protein Hsp27, which protects intestinal cells against oxidant-mediated tissue damage and loss of barrier function.

引用

页码：248 / 249

页数：2

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