A new copper-catalyzed [3+2] cycloaddition: Enantioselective coupling of terminal alkynes with azomethine imines to generate five-membered nitrogen heterocycles

被引：306

作者：

Shintani, R ^{[1
]}

Fu, GC ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 36期

关键词：

D O I：

10.1021/ja036922u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed method for the regioselective 1,3-dipolar cycloaddition of azomethine imines to terminal alkynes has been developed. Through the use of a chiral phosphaferrocene-oxazoline ligand, a wide range of substrates can be coupled to generate useful heterocycles in very good enantiomeric excess. Copyright © 2003 American Chemical Society.

引用

页码：10778 / 10779

页数：2

共 27 条

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