IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

被引：243

作者：

Rocken, M

Racke, M

Shevach, EM

机构：

[1] WASHINGTON UNIV, SCH MED, DEPT NEUROL & NEUROSURG, ST LOUIS, MO 63110 USA

[2] NIAID, IMMUNOL LAB, CELLULAR IMMUNOL SECT, BETHESDA, MD 20892 USA

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 05期

关键词：

D O I：

10.1016/0167-5699(96)80556-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Organ-specific autoimmune diseases are mediated by interferon gamma (IFN-gamma)-producing T helper 1 (Th1) cells. Here, Martin Rocken and colleagues review the experimental basis for an antigen-specific therapeutic approach to inflammatory autoimmune diseases. This strategy involves selective deviation of harmful Th1 responses towards an anti-inflammatory, interleukin 4 (IL-4)-producing Th2 phenotype.

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页码：225 / 231

页数：7

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