The odd couple: signal transduction and endocytosis

被引：73

作者：

Teis, D ^{[1
]}

Huber, LA ^{[1
]}

机构：

[1] Univ Innsbruck, Dept Histol & Mol Cell Biol, Inst Anat Histol & Embyol, A-6020 Innsbruck, Austria

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2003年 / 60卷 / 10期

关键词：

endocytosis; signaling; receptor tyrosine kinase; adaptor; scaffold complex; subcellular localization;

D O I：

10.1007/s00018-003-3010-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cell surface receptors are used to transmit extracellular information. The activation of cell surface receptors initiates signal transduction and receptor endocytosis. Signal transduction and the endosomal transport of activated receptors require precise regulation. New concepts for the integration of endocytosis and signaling arise from recent findings that suggest bidirectional interplay of these two processes. This review discusses the following questions: (i) do activated cell surface receptors modify the endosomal system to promote internalization and endosomal traffic, and (ii) do internalized cell surface receptors use specifically localized signaling complexes to generate specific biological signals?

引用

页码：2020 / 2033

页数：14

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