Naringin abrogates osteoclastogenesis and bone resorption via the inhibition of RANKL-induced NF-κB and ERK activation

被引：160

作者：

Ang, Estabelle S. M. ^{[2
]}

Yang, Xiaohong ^{[3
]}

Chen, Honghui ^{[3
]}

Liu, Qian ^{[4
]}

Zheng, Ming H. ^{[4
]}

Xu, Jiake ^{[1
]}

机构：

[1] Univ Western Australia, Sch Pathol & Lab Med, QEII Med Ctr, Nedlands, WA 6009, Australia

[2] Univ Western Australia, Sch Dent, Oral Biol Res Lab, Nedlands, WA 6009, Australia

[3] Jinan Univ, Guangzhou Inst Traumat Surg, Affiliated Hosp 4, Coll Med, Guangzhou 510220, Guangdong, Peoples R China

[4] Univ Western Australia, Ctr Orthopaed Res, Sch Surg, Nedlands, WA 6009, Australia

来源：

FEBS LETTERS | 2011年 / 585卷 / 17期

基金：

英国医学研究理事会;

关键词：

Naringin; Osteoclastogenesis; Bone resorption; RANKL; NF-kappa B; INDUCED GENOMIC INSTABILITY; RECEPTOR ACTIVATOR; ENDOTOXIN-SHOCK; PROTEIN-KINASE; MICE; DIFFERENTIATION; LIGAND; SUPPRESSION; INVOLVEMENT; PATHWAY;

D O I：

10.1016/j.febslet.2011.07.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteolytic bone diseases including osteoporosis are commonly accompanied with enhanced osteoclast formation and bone resorption. Naringin, a natural occurring flavonoid has been found to protect against retinoic acid-induced osteoporosis and improve bone quality in rats. Here, we showed that naringin perturbs osteoclast formation and bone resorption by inhibiting RANK-mediated NF-kappa B and ERK signaling. Naringin suppressed gene expression of key osteoclast marker genes. Naringin was found to inhibit RANKL-induced activation of NF-kappa B by suppressing RANKL-mediated I kappa B-alpha degradation. In addition, naringin inhibited RANKL-induced phosphorylation of ERK. This study identifies naringin as an inhibitor for osteoclast formation and bone resorption, and provides evidence that natural compounds such as naringin might be beneficial as an alternative medicine for the prevention and treatment of osteolysis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2755 / 2762

页数：8