Metabolomics in paediatric respiratory diseases and bronchiolitis

被引：33

作者：

Atzei, Alessandra ^{[1
,2
]}

Atzori, Luigi ^{[3
]}

Moretti, Corrado ^{[5
]}

Barberini, Luigi ^{[4
]}

Noto, Antonio ^{[1
,2
]}

Ottonello, Giovanni ^{[1
,2
]}

Pusceddu, Elisabetta ^{[1
,2
]}

Fanos, Vassilios ^{[1
,2
]}

机构：

[1] Univ Cagliari, Neonatal Intens Care Unit, Inst Puericulture, I-09124 Cagliari, Italy

[2] Univ Cagliari, Neonatal Sect, I-09124 Cagliari, Italy

[3] Univ Cagliari, Dept Toxicol, I-09124 Cagliari, Italy

[4] Univ Cagliari, Dept Neurol Sci, I-09124 Cagliari, Italy

[5] Univ Roma La Sapienza, Paediat Intens Care Unit, Rome, Italy

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2011年 / 24卷

关键词：

metabolomics; respiratory diseases; bronchiolitis; ASTHMA; INFANTS; UTILITY;

D O I：

10.3109/14767058.2011.607012

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

The metabolic study of an organism may make it possible to monitor, through the metabolites, the physiology and/or pathology of the organism itself. Metabolomics, in the strictest sense, "the set of metabolites, the final products of the genetic expression". Most clinical chemistry tests available today rely on old technologies that measure only a single chemical in blood, urine or other biofluids, and these tests are neither sensitive nor specific for any particular disease. Metabolomics offers a holistic approach to systems medicine, with the promise to enhance clinical chemistry diagnostics in several pathologic conditions. The present review covers the application of clinical metabolomics in three different areas of respiratory diseases in pediatrics: asthma, pneumonia and bronchiolitis. Comparison between two 1H-NMR urine spectra by two bronchiolitis patients are also presented.

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收藏

页码：60 / 63

页数：4

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