Beta-carotene supplementation: a good thing, a bad thing, or nothing?

被引：12

作者：

Christen, WG

Buring, JE

Manson, JE

Hennekens, CH

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Ambulatory Care & Prevent, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 01期

关键词：

D O I：

10.1097/00041433-199902000-00006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Available data from several completed large-scale randomized trials indicate that beta-carotene supplementation for durations up to 12 years has no overall benefit in well-nourished populations on the incidence of cardiovascular disease or the middle-to-late stages of carcinogenesis. Several important questions, however, remain unanswered. The post-trial followup of completed trials, together with the results of several ongoing trials of beta-carotene supplementation, will contribute reliable information to the totality of evidence from basic research, animal studies, observational epidemiologic studies, and completed trials, thus allowing more rational clinical decisions for individual patients and policy decisions for the health of the general public. Curr Opin Lipidol 10:29-33. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：29 / 33

页数：5

共 38 条

[1] Effects of supplemental beta-carotene, cigarette smoking, and alcohol consumption on serum carotenoids in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study [J].