Enhancement of diagnostic efficiency by a gamma interferon release assay for pulmonary tuberculosis

被引:16
作者
Kanunfre, Kelly Aparecida [1 ]
Munhoz Leite, Olavo Henrique [2 ]
Lopes, Max Igor [2 ]
Litvoc, Marcelo [2 ]
Ferreira, Antonio Walter [1 ,3 ]
机构
[1] Univ Sao Paulo, Inst Trop Med, Lab Soroepidemiol & Imunobiol, BR-05403000 Sao Paulo, Brazil
[2] Univ Sao Paulo, Sch Med, Hosp Clin, Clin Infect Dis, BR-05403000 Sao Paulo, Brazil
[3] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, BR-05403000 Sao Paulo, Brazil
关键词
D O I
10.1128/CVI.00026-08
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study was designed to examine the use of the QuantiFERON-TB Gold assay as an aid in the diagnosis of active pulmonary tuberculosis (TB) in Brazilian patients. Using the receiver operating characteristic curve, the cutoff was adjusted to >= 0.20 IU/ml. The sensitivity increased to 86%, with 100% specificity. All TB patients with negative sputum smear microscopy and negative culture results were positive using this test.
引用
收藏
页码:1028 / 1030
页数:3
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