1,2-Diaryl-1-ethanone and pyrazolo [4,3-c] quinoline-4-one as novel selective cyclooxygenase-2 inhibitors

被引：44

作者：

Baruah, B ^{[1
]}

Dasu, K ^{[1
]}

Vaitilingam, B ^{[1
]}

Vanguri, A ^{[1
]}

Casturi, SR ^{[1
]}

Yeleswarapu, KR ^{[1
]}

机构：

[1] Dr Reddys Labs Ltd, Inflammat Res Grp, Discovery Res, Hyderabad 500050, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.bmcl.2003.10.052

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel 1,2-diaryl-1-ethanone I and pyrazolo [4,3-c] quinoline-4-one 2, with pharmacophores different from the known COX inhibitors were identified as selective COX-2 inhibitors. The communication briefly describes SAR of both the series. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：445 / 448

页数：4

共 19 条

[1] Synthesis and structure -: Activity relationship of a new series of COX-2 selective inhibitors:: 1,5-diarylimidazoles [J].

Almansa, C ;

Alfón, J ;

de Arriba, AF ;

Cavalcanti, FL ;

Escamilla, I ;

Gómez, LA ;

Miralles, A ;

Soliva, R ;

Bartrolí, J ;

Carceller, E ;

Merlos, M ;

García-Rafanell, J .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (16) :3463-3475

[2] SYNTHESIS OF SUBSTITUTED 2-ETHYL-3-(4-HYDRAZINOCARBONYLPHENYL)-4-QUINAZOLONES AND 2-ETHYL-3-(4-HYDRAZINOCARBONYLMETHYLPHENYL)-4-QUINAZOLONES [J].

ARORA, RC ;

RASTOGI, VK ;

AGRAWAL, AK ;

PARMAR, SS .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1978, 15 (05) :869-871

[3] Aziridination of alkenes using 3-acetoxyamino-2-trifluoromethylquinazolin-4(3H)-one [J].

Atkinson, RS ;

Coogan, MP ;

Cornell, CL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (02) :157-166

[4]

BAHADUR S, 1983, CURR SCI INDIA, V52, P910

[5] STUDIES OF RUTAECARPINE AND RELATED QUINAZOLINOCARBOLINE ALKALOIDS [J].

BERGMAN, J ;

BERGMAN, S .

JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (08) :1246-1255

[6]

BUYUKTIMKIN S, 1985, PHARMAZIE, V40, P393

[7]

Chan CC, 1999, J PHARMACOL EXP THER, V290, P551

[8] MECHANISM OF SELECTIVE-INHIBITION OF THE INDUCIBLE ISOFORM OF PROSTAGLANDIN G/H SYNTHASE [J].

COPELAND, RA ;

WILLIAMS, JM ;

GIANNARAS, J ;

NURNBERG, S ;

COVINGTON, M ;

PINTO, D ;

PICK, S ;

TRZASKOS, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) :11202-11206

[9] Cyclooxygenase inhibitors - current status and future prospects [J].

Dannhardt, G ;

Kiefer, W .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2001, 36 (02) :109-126

[10]

Hawley C., 1999, LANCET, V353, P307

← 1 2 →