Catalytic ester-amide exchange using group (IV) metal alkoxide-activator complexes

被引：157

作者：

Han, C

Lee, JP

Lobkovsky, E

Porco, JA ^{[1
]}

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Ctr Chem Methodol & Lib Dev, Boston, MA 02215 USA

[3] Cornell Univ, Baker Lab, Dept Chem, Ithaca, NY 14583 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 28期

关键词：

D O I：

10.1021/ja0527976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A process for preparation of amides from unactivated esters and amines has been developed using a catalytic system comprised of group (IV) metal alkoxides in conjunction with additives including 1-hydroxy-7-azabenzotriazole (HOAt). In general, ester-amide exchange proceeds using a variety of structurally diverse esters and amines without azeotropic reflux to remove the alcohol byproduct. Initial mechanistic studies on the Zr(Ot-Bu)(4)-HOAt system revealed that the active catalyst is a novel, dimeric zirconium complex as determined by X-ray crystallography.

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收藏

页码：10039 / 10044

页数：6

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