Proton-linked bi- and tri-metallic gold cyanide complexes observed by ESI-MS spectrometry

被引：5

作者：

Yangyuoru, Philip M. ^{[1
]}

Webb, James W. ^{[1
]}

Shaw, C. F., III ^{[1
]}

机构：

[1] Illinois State Univ, Dept Chem, Normal, IL 61791 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2008年 / 102卷 / 03期

关键词：

electrospray ionization mass spectrometry; gold(I); gold(III); cyanide; proton-linked; CRYSTAL-STRUCTURE; METABOLITES; ACTIVATION; PHASE;

D O I：

10.1016/j.jinorgbio.2007.10.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electrospray ionization spectra of potential cyanide-containing gold-drug metabolites revealed additional, weak, unanticipated peaks at approximately twice the mass of the gold(I) and gold(III) cyanide complexes. The exact masses correspond to proton-linked bimetallic complexes, [H{Au(CN)(m)}(2)](-), (m=2,4). Further investigation revealed a total of 12 examples, including trimetallic complexes, [H-2{Au(CN)(m)}(3)](-); mixed species with two complexes, [H{Au(CN)(2)}{Au(CN)(4)}](-); and thiolato species, [H{(RS)Au(CN)(3)}(2)](-) , trans-[AuX2(CN)(2)Cl-2](-) and trans-[AuX2(CN)(2)Br-2](-) generated (CI)-C-35/(17) Cl and Br-79/Br-81 isotopic patterns for the protonated bi- and tri-metallic analogues which were in good agreement with the presence of four or six halide ligands, respectively. Concentration-dependent studies demonstrated that the signals are independent of the solution concentrations of mono-metallic precursors, suggesting formation in the gas phase during or following droplet desolvation. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：576 / 583

页数：8

共 33 条

[1]

ALBORES P, 2006, J CHEM SOC DA, P948

[2] Ancillary ligand control of reactivity. Protonation at hydride vs cyanide in trans-[FeH(CN)(R(2)PCH(2)CH(2)PR(2))(2)] (R=Et, Ph, p-tolyl) and X-ray crystal structure determination of trans-[FeH(CNH)(R(2)PCH(2)CH(2)PR(2))2]BF4 (R=p-tolyl) [J].

Amrhein, PI ;

Drouin, SD ;

Forde, CE ;

Lough, AJ ;

Morris, RH .

CHEMICAL COMMUNICATIONS, 1996, (14) :1665-1666

[3] CRYSTAL STRUCTURE OF POTASSIUM SALT OF GOLD CYANIDE COMPLEX MONOHYDRATE BY NEUTRON DIFFRACTION [J].

BERTINOTTI, C ;

BERTINOT.A .

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL CRYSTALLOGRAPHY AND CRYSTAL CHEMISTRY, 1970, B 26 :422-+

[4] Redox and ligand exchange reactions of potential gold(I) and gold(III)-cyanide metabolites under biomimetic conditions [J].

Canumalla, AJ ;

Al-Zamil, N ;

Phillips, M ;

Isab, AA ;

Shaw, CF .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 85 (01) :67-76

[5] Preparative and structural studies on the carbonyl cyanides of iron, manganese, and ruthenium: Fundamentals relevant to the hydrogenases [J].

Contakes, SM ;

Hsu, SCN ;

Rauchfuss, TB ;

Wilson, SR .

INORGANIC CHEMISTRY, 2002, 41 (06) :1670-1678

[6] The structures of [24-pyrimidinium crown-6] [Au(CN)2]4(NO3)2•2H2O, [24-pyrimidinium crown-6][Au(CN)2]6•5H2O, and [16-pyrimidinium crown-4][Au(CN)2]4•6.5 H2O, in which aurophilic interactions produce trimers, tetramers, and chains of Au(CN)2- ions [J].

Cramer, RE ;

Smith, DW ;

VanDoorne, W .

INORGANIC CHEMISTRY, 1998, 37 (22) :5895-5901

[7] THE CRYSTAL STRUCTURES OF HYDROGEN CYANIDE, HCN [J].

DULMAGE, WJ ;

LIPSCOMB, WN .

ACTA CRYSTALLOGRAPHICA, 1951, 4 (04) :330-334

[8]

ELDER RC, 1993, J RHEUMATOL, V20, P268

[9] The activation of gold complexes by cyanide produced by polymorphonuclear leukocytes - III. The formation of aurocyanide by myeloperoxidase [J].

Graham, GG ;

Kettle, AJ .

BIOCHEMICAL PHARMACOLOGY, 1998, 56 (03) :307-312

[10]

HAMILTON WC, 1968, HYDROGEN BONDING SOL, P219

← 1 2 3 4 →