Trithorax group proteins: switching genes on and keeping them active

被引：337

作者：

Schuettengruber, Bernd ^{[1
]}

Martinez, Anne-Marie ^{[1
,2
]}

Iovino, Nicola ^{[1
]}

Cavalli, Giacomo ^{[1
]}

机构：

[1] CNRS, Inst Genet Humaine, F-34396 Montpellier 5, France

[2] Univ Montpellier 2, F-34095 Montpellier 5, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 12期

基金：

欧洲研究理事会;

关键词：

CHROMATIN-REMODELING COMPLEXES; EMBRYONIC STEM-CELLS; POLYCOMB GROUP; HISTONE H3; SELF-RENEWAL; TUMOR-SUPPRESSOR; DROSOPHILA-TRITHORAX; NONCODING RNAS; MLL FAMILY; TRANSCRIPTION ELONGATION;

D O I：

10.1038/nrm3230

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cellular memory is provided by two counteracting groups of chromatin proteins termed Trithorax group (TrxG) and Polycomb group (PcG) proteins. TrxG proteins activate transcription and are perhaps best known because of the involvement of the TrxG protein MLL in leukaemia. However, in terms of molecular analysis, they have lived in the shadow of their more famous counterparts, the PcG proteins. Recent advances have improved our understanding of TrxG protein function and demonstrated that the heterogeneous group of TrxG proteins is of critical importance in the epigenetic regulation of the cell cycle, senescence, DNA damage and stem cell biology.

引用

页码：799 / 814

页数：16

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