Prevention and treatment of MS: studying the effects of vitamin D

被引：46

作者：

Munger, Kassandra L. ^{[1
]}

Ascherio, Alberto ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2011年 / 17卷 / 12期

关键词：

clinical trials; multiple sclerosis; prevention; treatment; vitamin D; MULTIPLE-SCLEROSIS EXACERBATIONS; RESONANCE-IMAGING LESIONS; 25-HYDROXYVITAMIN-D LEVELS; SEASONAL FLUCTUATIONS; D SUPPLEMENTATION; DISEASE-ACTIVITY; SUN EXPOSURE; RISK; CALCIUM; POPULATION;

D O I：

10.1177/1352458511425366

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Observational studies suggest that adequate vitamin D nutrition may reduce the risk of MS and affect the course of the disease. Inherent limitations in these studies, however, preclude a causal interpretation. Randomized controlled clinical trials are the next step to addressing whether vitamin D prevents MS or can favorably affect the course and progression of MS. Here we briefly review the current literature on vitamin D and MS, both as a risk factor and potential treatment for MS with a focus on the issues and challenges in designing prevention and treatment clinical trials.

引用

页码：1405 / 1411

页数：7

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