Light activated RNA interference

被引：160

作者：

Shah, S ^{[1
]}

Rangarajan, S ^{[1
]}

Friedman, SH ^{[1
]}

机构：

[1] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64110 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 09期

关键词：

gene expression; oligonucleotides; photochemistry; photolysis; RNA recognition;

D O I：

10.1002/anie.200461458

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Light-controlled gene expression: Cellular mRNA levels that are regulated by the RNA interference pathway can now be controlled with light. The modification of small interfering RNA (siRNA) with photolabile moieties can partially or fully block RNA interference, depending on the extent of siRNA modification. Upon irradiation, siRNA is released (see picture). Now in its active state, it is able to suppress target gene expression. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1328 / 1332

页数：5

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