Citridones, new potentiators of antifungal miconazole activity, produced by Penicillium sp FKI-1938I.: Taxonomy, fermentation, isolation and biological properties

被引：37

作者：

Fukuda, T

Yamaguchi, Y

Masuma, R

Tomoda, H

Omura, S

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

[4] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2005年 / 58卷 / 05期

关键词：

citridones; anti-infective; azole potentiator; Penicillium;

D O I：

10.1038/ja.2005.38

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New phenylfuropyridinones and related compounds, designated citridones A, B, B' and C, were isolated along with known CJ-16,173, from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Citridones (75 mu M) potentiate the miconazole activity against Candida albicans, decreasing the IC50 value of miconazole from 14.5 nM to 3.5 similar to 6.3 nM.

引用

页码：309 / 314

页数：6

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