Senseless acts as a binary switch during sensory organ precursor selection

被引：108

作者：

Jafar-Nejad, H

Acar, M

Nolo, R

Lacin, H

Pan, HL

Parkhurst, SM

Bellen, HJ ^{[1
]}

机构：

[1] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

[2] Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[4] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA

[5] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

来源：

GENES & DEVELOPMENT | 2003年 / 17卷 / 23期

关键词：

neuronal specification; proneural genes; enhancer of split; Drosophila; peripheral nervous system development;

D O I：

10.1101/gad.1122403

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During sensory organ precursor (SOP) specification, a single cell is selected from a proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger transcription factor, plays an important role in this process. We show that Sens is directly activated by proneural proteins in the presumptive SOPs and a few cells surrounding the SOP in most tissues. In the cells that express low levels of Sens, it acts in a DNA-binding-dependent manner to repress transcription of proneural genes. In the presumptive SOPs that express high levels of Sens, it acts as a transcriptional activator and synergizes with proneural proteins. We therefore propose that Sens acts as a binary switch that is fundamental to SOP selection.

引用

页码：2966 / 2978

页数：13