Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis

被引:63
作者
Kang, Nam Joo [6 ]
Jung, Sung Keun [5 ]
Lee, Ki Won [2 ,3 ,4 ]
Lee, Hyong Joo [1 ,2 ]
机构
[1] Seoul Natl Univ, Dept Agr Biotechnol, WCU Biomodulat Program, Seoul 151921, South Korea
[2] Seoul Natl Univ, Ctr Agr Biomat, Seoul 151921, South Korea
[3] Adv Inst Convergence Technol, Suwon, Gyeonggi Do, South Korea
[4] Seoul Natl Univ, Dept Agr Biotechnol, Food Sci & Biotechnol Program, Seoul 151921, South Korea
[5] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA
[6] Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Taegu, South Korea
来源
NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER | 2011年 / 1229卷
关键词
myricetin; skin carcinogenesis; chemoprevention; signaling pathway; OCCURRING PLANT PHENOLS; IN-VIVO; CYCLOOXYGENASE-2; EXPRESSION; EXCEPTIONAL ACTIVITY; CELL-TRANSFORMATION; ULTRAVIOLET-LIGHT; ANGIOGENIC SWITCH; TUMOR PROMOTION; MAP KINASES; KAPPA-B;
D O I
10.1111/j.1749-6632.2011.06122.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Myricetin is a widely distributed flavonol that is found in many plants, including tea, berries, fruits, vegetables, and medicinal herbs. Abundant sources provide interesting insights into the multiple mechanisms by which myricetin mediates chemopreventive effects on skin cancer. Myricetin strongly inhibited tumor promoter-induced neoplastic cell transformation by inhibiting MEK, JAK1, Akt, and MKK4 kinase activity directly. In a mouse skin model, myricetin attenuated the ultraviolet B (UVB)-induced COX-2 expression and skin tumor formation by regulating Fyn. Myricetin-mediated inactivation of Akt in the UVB response plays a role in regulating UVB-induced carcinogenesis. Recently, myricetin was found to inhibit UVB-induced angiogenesis by targeting PI3-K in an SKH-1 hairless mouse skin tumorigenesis model. Raf Icinase is a critical target for myricetin in inhibiting the UVB-induced formation of wrinkles and suppression of type I procollagen and collagen levels in mouse skin. Accumulated data suggest that myricetin acts as a promising agent for the chemoprevention of skin cancer.
引用
收藏
页码:124 / 132
页数:9
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