High prevalence of anal squamous intraepithelial lesions in HIV-positive men despite the use of highly active antiretroviral therapy

被引:116
作者
Piketty, C
Darragh, TM
Heard, I
Da Costa, M
Bruneval, P
Kazatchkine, MD
Palefsky, JM
机构
[1] Univ Paris 06, Hop Europeen Georges Pompidou, F-75015 Paris, France
[2] INSERM, U430, Dept Immunol, F-75015 Paris, France
[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[5] Hop Europeen Georges Pompidou, Dept Pathol, Paris, France
关键词
D O I
10.1097/01.OLQ.0000109515.75864.2B
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Baekground: The impact of highly active antiretroviral therapy (HAART) on the natural history of HPV infection and anal squamous intraepithelial lesions (SIL) in HIV-infected men who have sex with men (MSM) is poorly documented. Goal: The goal of this study was to evaluate the prevalence of anal HPV infection and SIL inpatients under HAART. Study Design: Forty-five HIV-infected protease inhibitor-experienced MSM were enrolled in a cross-sectional study. Each patient provided anal samples for anal cytology, histology, and human papilllomavirus (HPV) DNA testing. Results: The patients had previously received HAART for a median of 32 months. Anal cytology was abnormal in 32 of 45 (71%) patients, including high-grade SIL in 10 patients (22%), low-grade SIL in 19 patients (42%), and atypical squamous cells of undetermined significance in 3 patients (7%). HPV DNA was detected 36/45 men (80%). The prevalence of anal SIL and HPV infection were similar in patients exhibiting a significant increase in CD4+ cell count after HAART initiation compared with those who did not. Conclusion: Our results demonstrate a high prevalence of anal SIL, including high-grade SIL, and anal HPV infection in HIV-infected MSM despite immune restoration under HAART.
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收藏
页码:96 / 99
页数:4
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