Cytotoxic T cells - Stroma interactions

被引：5

作者：

Noman, Muhammad Zaeem ^{[1
]}

Benlalam, Houssem

Hasmim, Meriem

Chouaib, Salem

机构：

[1] Inst Gustave Roussy, INSERM, U753, PR1, F-94805 Villejuif, France

来源：

BULLETIN DU CANCER | 2011年 / 98卷 / 02期

关键词：

hypoxia; STAT3; HIF-1; alpha; endothelial cells; tumor cells; CTLs; SINUSOIDAL ENDOTHELIAL-CELLS; TUMOR MICROENVIRONMENT; CROSS-PRESENTATION; APOPTOTIC BODIES; COLON-CANCER; HYPOXIA; ANTIGEN; IMMUNOTHERAPY; METASTASIS; TOLERANCE;

D O I：

10.1684/bdc.2010.1295

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor microenvironment is a complex system playing an important role in tumor development and progression. Besides tumor cells, the tumor microenvironment harbours a variety of host-derived cells, such as endothelial cells, fibroblasts, innate and adaptive immune cells, as well as extracellular matrix (ECM) fibers, cytokines, and other mediators. This review discusses the potential role of hypoxia and endothelial cells within tumor microenvironment and emphasizes their interaction with antigen specific killer cells.

引用

页码：E19 / E24

页数：6

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