The role of Helicobacter pylori in children with chronic idiopathic thrombocytopenic purpura

被引：21

作者：

Bisogno, Gianni ^{[1
]}

Errigo, Gabriella ^{[1
]}

Rossetti, Flavio ^{[3
]}

Sainati, Laura ^{[1
]}

Pusiol, Anna ^{[4
]}

Da Dalt, Liviana ^{[2
]}

Colleselli, Paolo ^{[5
]}

Grotto, Paolo ^{[6
]}

Carli, Modesto ^{[1
]}

机构：

[1] Univ Hosp Padova, Dept Pediat, Div Hematol Oncol, I-35128 Padua, Italy

[2] Univ Hosp Padova, Dept Pediat, Emergency Unit, Padua, Italy

[3] Hosp Monselice, Pediat Unit, Monselice, Italy

[4] Univ Hosp Udine, Div Pediat, Udine, Italy

[5] Hosp Vicenza, Pediat Unit, Vicenza, Italy

[6] Hosp Belluno, Pediat Unit, Belluno, Italy

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2008年 / 30卷 / 01期

关键词：

children; chronic idiopathic thrombocytopenic purpura; eradication therapy; Helicobacter pylori;

D O I：

10.1097/MPH.0b013e3181615613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent reports have suggested that Helicobacter pylori infection may be a causative agent of adult chronic idiopathic thrombocytopenic purpura (cITP) and antimicrobial treatment may increase platelet counts. As there is limited experience in pediatric age, we investigated the prevalence of H. pylori infection and the effects of H. pylori eradication therapy in a series of children with cITP. Twenty-four children with cITP were investigated for H. pylori infection using the C-13- urea breath test or H. pylori fecal antigen. In cases of H. pylori infection, antimicrobial treatment was given with amoxicillin, clarithromycin, and proton pump inhibitors. Response was assessed at 6 months and defined as complete (platelet count > 150 x 10(9)/L) or partial (platelet count between 50 and 150 x 10(9)/L). H. pylori infection was found in 8 patients (33%) and 3 of them showed a response after eradication therapy, but 2 of them relapsed later on. Two patients had a spontaneous increase in platelet count in the group of H. pylori-negative patients. Given that spontaneous improvements in platelet count can occur in children with cITP, we were unable to demonstrate that H. pylori plays a major role in cITP occurring in pediatric age.

引用

页码：53 / 57

页数：5