Fluorescent sensor array in a microfluidic chip

被引：28

作者：

Basabe-Desmonts, Lourdes ^{[1
,3
]}

Benito-Lopez, Fernando ^{[1
]}

Gardeniers, Han J. G. E. ^{[2
]}

Duwel, Rob ^{[2
]}

van den Berg, Albert ^{[2
]}

Reinhoudt, David N. ^{[1
]}

Crego-Calama, Mercedes ^{[1
,4
]}

机构：

[1] Univ Twente, Inst Nanotechnol, Dept Supramol Chem & Technol, MESA, NL-7500 AE Enschede, Netherlands

[2] Univ Twente, Inst Nanotechnol, MESA, BIOS Lab Chip Grp, NL-7500 AE Enschede, Netherlands

[3] Dublin City Univ, Biomed Diagnost Inst, Dublin 9, Ireland

[4] Holst Ctr, Stichting IMEC Nederland, NL-5605 KN Eindhoven, Netherlands

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2008年 / 390卷 / 01期

关键词：

microchannels; fluorescent sensors; array; SAMs; combinatorial;

D O I：

10.1007/s00216-007-1720-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Miniaturization and automation are highly important issues for the development of high-throughput processes. The area of micro total analysis systems (mu TAS) is growing rapidly and the design of new schemes which are suitable for miniaturized analytical devices is of great importance. In this paper we report the immobilization of self-assembled monolayers (SAMs) with metal ion sensing properties, on the walls of glass microchannels. The parallel combinatorial synthesis of sensing SAMs in individually addressable microchannels towards the generation of optical sensor arrays and sensing chips has been developed.

引用

页码：307 / 315

页数：9

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