Comparison of long and short axis quantification of left ventricular volume parameters by cardiovascular magnetic resonance, with ex-vivo validation

被引:82
作者
Childs, Helene [1 ,2 ]
Ma, Lucia [1 ,2 ]
Ma, Michael [1 ,2 ]
Clarke, James [3 ]
Cocker, Myra [1 ,2 ]
Green, Jordin [1 ,2 ,4 ]
Strohm, Oliver [1 ,2 ]
Friedrich, Matthias G. [1 ,2 ]
机构
[1] Univ Calgary, Dept Cardiac Sci, Libin Cardiovasc Inst Alberta, Stephenson Cardiovasc MR Ctr, Calgary, AB T2N 1N4, Canada
[2] Univ Calgary, Dept Radiol, Libin Cardiovasc Inst Alberta, Stephenson Cardiovasc MR Ctr, Calgary, AB T2N 1N4, Canada
[3] Dalhousie Univ, Dept Nucl Med & Radiol, Halifax, NS, Canada
[4] Siemens Healthcare, Erlangen, Germany
关键词
STATE FREE PRECESSION; MYOCARDIAL MASS; MRI;
D O I
10.1186/1532-429X-13-40
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The purpose of the study was to compare the accuracy and evaluation time of quantifying left ventricular (LV), left atrial (LA) volume and LV mass using short axis (SAX) and long axis (LAX) methods when using cardiovascular magnetic resonance (CMR). Materials and methods: We studied 12 explanted canine hearts and 46 patients referred for CMR (29 male, age 47 +/- 18 years) in a clinical 1.5 T CMR system, using standard cine sequences. In standard short axis stacks of various slice thickness values in dogs and 8 mm slice thickness (gap 2 mm) in patients, we measured LV volumes using reference slices in a perpendicular, long axis orientation using certified software. Volumes and mass were also measured in six radial long axis (LAX) views. LV parameters were also assessed for intra-and inter-observer variability. In 24 patients, we also analyzed reproducibility and evaluation time of two very experienced (> 10 years of CMR reading) readers for SAX and LAX. Results: In the explanted dog hearts, there was excellent agreement between ex vivo data and LV mass and volume data as measured by all methods for both, LAX (r(2) = 0.98) and SAX (r(2) = 0.88 to 0.98). LA volumes, however, were underestimated by 13% using the LAX views. In patients, there was a good correlation between all three assessed methods (r(2) >= 0.95 for all). In experienced clinical readers, left-ventricular volumes and ejection fraction as measured in LAX views showed a better inter-observer reproducibility and a 27% shorter evaluation time. Conclusion: When compared to an ex vivo standard, both, short axis and long axis techniques are highly accurate for the quantification of left ventricular volumes and mass. In clinical settings, however, the long axis approach may be more reproducible and more time-efficient. Therefore, the rotational long axis approach is a viable alternative for the clinical assessment of cardiac volumes, function and mass.
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