Sialoside-based pattern recognitions discriminating infections from tissue injuries

被引：22

作者：

Liu, Yang ^{[1
,2
]}

Chen, Guo-Yun ^{[1
,2
]}

Zheng, Pan ^{[1
,3
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Div Immunotherapy, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2011年 / 23卷 / 01期

基金：

美国国家卫生研究院;

关键词：

MEMBRANE-ASSOCIATED SIALIDASE; NALP3; INFLAMMASOME; IMMUNE-SYSTEM; APOPTOSIS SUPPRESSION; NLRP3; ACTIVATION; CELLS; CD24; AUTOIMMUNITY; RESPONSES;

D O I：

10.1016/j.coi.2010.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition of pathogens-associated molecular patterns (PAMPs) by Toll-like receptors (TLRs), NOD-like receptors (NILRs) and RIG-I-like receptors (RLR) plays a critical role in protecting host against pathogens. In addition, TLR and NLR also recognize danger-associated molecular patterns (DAMPs) to initiate limited innate immune responses. While innate immune response to DAMPs may be important for tissue repairs and wound healing, it is normally well controlled to avoid autoimmune destruction. Recent data support a role for sialoside-based pattern recognition by members of the Siglec family to attenuate innate immunity. In particular, since CD24-Siglec 10/G interaction selectively dampens host response to DAMPs but not PAMPs, this sialoside-based pattern recognition may serve as a foundation to discriminate PAMPs from DAMPs.

引用

收藏

页码：41 / 45

页数：5

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