Protein quality control in Alzheimer's disease by the ubiquitin proteasome system

被引：133

作者：

de Vrij, FMS ^{[1
]}

Fischer, DF ^{[1
]}

van Leeuwen, FW ^{[1
]}

Hol, EM ^{[1
]}

机构：

[1] Netherlands Inst Brain Res, Grad Sch Neurosci, NL-1105 AZ Amsterdam, Netherlands

来源：

PROGRESS IN NEUROBIOLOGY | 2004年 / 74卷 / 05期

关键词：

D O I：

10.1016/j.pneurobio.2004.10.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ubiquitin proteasome system (UPS) is the major protein quality control system in eukaryotic cells. Many neurodegenerative diseases are characterized by aggregates and inclusions of aberrant proteins, implying a sub-optimal functioning or defective UPS. The last few years have seen increasing evidence for the involvement of the UPS in neurodegenerative disorders, including Alzheimer's disease (AD). Notably, decreases in proteasome activity were detected in several cortical areas in AD patients. In addition, proteins that accumulate in the classical hallmarks of AD were linked to UPS function. This review specifically discusses the involvement of the UPS in AD pathogenesis. First, a detailed overview of the UPS is presented, after which AD pathology and its relation to the UPS is discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：249 / 270

页数：22

共 239 条

[41] Proteasomal degradation of tau protein
David, DC
Layfield, R
Serpell, L
Narain, Y
Goedert, M
Spillantini, MG
[J]. JOURNAL OF NEUROCHEMISTRY, 2002, 83 (01) : 176 - 185
[42] Accumulation of aberrant ubiquitin induces aggregate formation and cell death in polyglutamine diseases
de Pril, R
Fischer, DF
Maat-Schieman, MLC
Hobo, B
de Vos, RAI
Brunt, ER
Hol, EM
Roos, RAC
van Leeuwen, FW
[J]. HUMAN MOLECULAR GENETICS, 2004, 13 (16) : 1803 - 1813
[43] Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex
De Strooper, B
[J]. NEURON, 2003, 38 (01) : 9 - 12
[44] Mutant ubiquitin expressed in Alzheimer's disease causes neuronal death
De Vrij, FMS
Sluijs, JA
Gregori, L
Fischer, DF
Hermens, WTJMC
Goldgaber, D
Verhaagen, J
Van Leeuwen, FW
Hol, EM
[J]. FASEB JOURNAL, 2001, 15 (14) : 2680 - 2688
[45] Ubiquitination-dependent mechanisms regulate synaptic growth and function
DiAntonio, A
Haghighi, AP
Portman, SL
Lee, JD
Amaranto, AM
Goodman, CS
[J]. NATURE, 2001, 412 (6845) : 449 - 452
[46] Díaz-Hernández M, 2003, J NEUROSCI, V23, P11653
[47] Dickey CA, 2003, J NEUROSCI, V23, P5219
[48] Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress
Ding, QX
Reinacker, K
Dimayuga, E
Nukala, V
Drake, J
Butterfield, DA
Dunn, JC
Martin, S
Bruce-Keller, AJ
Keller, JN
[J]. FEBS LETTERS, 2003, 546 (2-3): : 228 - 232
[49] Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival
Ding, QX
Lewis, JJ
Strum, KM
Dimayuga, E
Bruce-Keller, AJ
Dunn, JC
Keller, JN
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (16) : 13935 - 13942
[50] Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins
Ding, QX
Keller, JN
[J]. JOURNAL OF NEUROCHEMISTRY, 2001, 77 (04) : 1010 - 1017

← 1 2 3 4 5 6 7 8 9 10 →