Protein microarrays as tools for functional proteomics

被引：188

作者：

LaBaer, J ^{[1
]}

Ramachandran, N ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Harvard Inst Proteom, Dept Biol Chem & Mol Pharmacol, Cambridge, MA 02141 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2005年 / 9卷 / 01期

关键词：

D O I：

10.1016/j.cbpa.2004.12.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein microarrays present an innovative and versatile approach to study protein abundance and function at an unprecedented scale. Given the chemical and structural complexity of the proteome, the development of protein microarrays has been challenging. Despite these challenges there has been a marked increase in the use of protein microarrays to map interactions of proteins with various other molecules, and to identify potential disease biomarkers, especially in the area of cancer biology. In this review, we discuss some of the promising advances made in the development and use of protein microarrays.

引用

页码：14 / 19

页数：6

共 34 条

[11]

Holz Caterina, 2003, Journal of Structural and Functional Genomics, V4, P97, DOI 10.1023/A:1026226429429

[12] Simultaneous detection of multiple cytokines from conditioned media and patient's sera by an antibody-based protein array system [J].

Huang, RP ;

Huang, RC ;

Fan, Y ;

Lin, Y .

ANALYTICAL BIOCHEMISTRY, 2001, 294 (01) :55-62

[13]

Jona G, 2003, CURR OPIN MOL THER, V5, P271

[14] Gene expression profile analysis by DNA microarrays - Promise and pitfalls [J].

King, HC ;

Sinha, AA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (18) :2280-2288

[15] Tissue microarrays for high-throughput molecular profiling of tumor specimens [J].

Kononen, J ;

Bubendorf, L ;

Kallioniemi, A ;

Bärlund, M ;

Schraml, P ;

Leighton, S ;

Torhorst, J ;

Mihatsch, MJ ;

Sauter, G ;

Kallioniemi, OP .

NATURE MEDICINE, 1998, 4 (07) :844-847

[16] Protein micro- and macroarrays: digitizing the proteome [J].

Lopez, MF ;

Pluskal, MG .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 787 (01) :19-27

[17] Protein microarrays and proteomics [J].

MacBeath, G .

NATURE GENETICS, 2002, 32 (Suppl 4) :526-532

[18]

MacBeath G, 2000, SCIENCE, V289, P1760

[19] Analyzing antibody specificity with whole proteome microarrays [J].

Michaud, GA ;

Salcius, M ;

Zhou, F ;

Bangham, R ;

Bonin, J ;

Guo, H ;

Snyder, M ;

Predki, PF ;

Schweitzer, BI .

NATURE BIOTECHNOLOGY, 2003, 21 (12) :1509-1512

[20] Antibody microarray profiling of human prostate cancer sera: Antibody screening and identification of potential biomarkers [J].

Miller, JC ;

Zhou, HP ;

Kwekel, J ;

Cavallo, R ;

Burke, J ;

Butler, EB ;

Teh, BS ;

Haab, BB .

PROTEOMICS, 2003, 3 (01) :56-63

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