Role of protein kinase C and mitochondrial permeability transition pore in the neuroprotective effect of ceramide in ischemia-induced cell death

被引：29

作者：

Agudo-Lopez, Alba ^{[1
]}

Miguel, Begona G. ^{[1
]}

Fernandez, Inmaculada ^{[1
]}

Martinez, Ana M. ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Quim, Dept Bioquim & Biol Mol 1, E-28040 Madrid, Spain

来源：

FEBS LETTERS | 2011年 / 585卷 / 01期

关键词：

Ceramide; Ischemia; Mitochondria; Neuroprotection; PKC-EPSILON; INVOLVEMENT; PROTECTION; TRANSIENT; STRESS; ZETA;

D O I：

10.1016/j.febslet.2010.11.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we investigated the role of protein kinase C (PKC) and mitochondrial permeability transition pore (mPTP) on the effect of ceramide in an in vitro model of ischemia in SH-SY5Y neuroblastoma cells. In ischemic cell viability studies, a dual effect of ceramide was observed, depending on ceramide concentration. PKC isoforms are involved in the protective effect of low concentrations of ceramide. During ischemia, ceramide treatment leads to an increase in the formation of reactive oxygen species (ROS), which induces a controlled opening of mPTP. This fact prevents mitochondrial Ca2+ overload, which is clearly protective. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：99 / 103

页数：5

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