Precision medicine in airway diseases: moving to clinical practice

被引：134

作者：

Agusti, Alvar ^{[1
,2
]}

Bafadhel, Mona ^{[3
]}

Beasley, Richard ^{[4
]}

Bel, Elisabeth H. ^{[5
]}

Faner, Rosa ^{[2
]}

Gibson, Peter G. ^{[6
,7
]}

Louis, Renaud ^{[8
]}

McDonald, Vanessa M. ^{[6
,7
]}

Sterk, Peter J. ^{[5
]}

Thomas, Mike ^{[9
]}

Vogelmeier, Claus ^{[10
]}

Pavord, Ian D. ^{[3
,11
,12
]}

机构：

[1] Univ Barcelona, Resp Inst, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain

[2] Ctr Invest Biomed Red Enfermedades Resp CIBERES, Barcelona, Spain

[3] Univ Oxford, Nuffield Dept Med, Dept Resp Med, Oxford, England

[4] Med Res Inst New Zealand, Wellington, New Zealand

[5] Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands

[6] Univ Newcastle, Prior Res Ctr Hlth Lungs, Ctr Excellence Severe Asthma, Newcastle, NSW, Australia

[7] Hunter Med Res Inst, Newcastle, NSW, Australia

[8] Univ Liege, Pneumol Dept, GIGA Res Grp I3, CHU Liege, Liege, Belgium

[9] Univ Southampton, Aldermoor Hlth Ctr, Primary Care & Populat Sci, Southampton, Hants, England

[10] Univ Marburg, German Ctr Lung Res DZL, Marburg, Germany

[11] Univ Oxford, Oxford NIHR Biomed Res Ctr, Oxford, England

[12] Oxford Univ Hosp NHS Fdn Trust, Oxford, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2017年 / 50卷 / 04期

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; EXHALED NITRIC-OXIDE; RANDOMIZED CONTROLLED-TRIALS; BLOOD EOSINOPHIL COUNT; LUNG-FUNCTION DECLINE; DOUBLE-BLIND; MULTIDIMENSIONAL ASSESSMENT; BIOMARKER DISCOVERY; EXTERNAL VALIDITY; ALLERGIC-ASTHMA;

D O I：

10.1183/13993003.01655-2017

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

On February 21, 2017, a European Respiratory Society research seminar held in Barcelona discussed how to best apply precision medicine to chronic airway diseases such as asthma and chronic obstructive pulmonary disease. It is now clear that both are complex and heterogeneous diseases, that often overlap and that both require individualised assessment and treatment. This paper summarises the presentations and discussions that took place during the seminar. Specifically, we discussed the need for a new taxonomy of human diseases, the role of different players in this scenario (exposome, genes, endotypes, phenotypes, biomarkers and treatable traits) and a number of unanswered key questions in the field. We also addressed how to deploy airway precision medicine in clinical practice today, both in primary and specialised care. Finally, we debated the type of research needed to move the field forward. Many common human diseases are still diagnosed as if they are homogeneous entities, using criteria that have hardly changed in a century.. the treatment for diseases that are diagnosed in this way is generic, with empiricism as its cornerstone

引用

页数：13

共 80 条

[61] Time for one-person trials [J].