Efficient and general protocol for the copper-free Sonogashira coupling of aryl bromides at room temperature

被引：244

作者：

Soheili, A ^{[1
]}

Albaneze-Walker, J ^{[1
]}

Murry, JA ^{[1
]}

Dormer, PG ^{[1
]}

Hughes, DL ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 22期

关键词：

D O I：

10.1021/ol035632f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and general protocol for the copper-free Sonogashira coupling of aryl bromides with acetylenes has been developed. The use of (AllylPdCl)(2) and P(t-Bu)(3) provides the active Pd(0) catalyst that allows subsequent coupling of various alkynes at room temperature with good to excellent yields.

引用

页码：4191 / 4194

页数：4

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