Synapses form in skeletal muscles lacking neuregulin receptors

被引：100

作者：

Escher, P ^{[1
]}

Lacazette, E

Courtet, M

Blindenbacher, A

Landmann, L

Bezakova, G

Lloyd, KC

Mueller, U

Brenner, HR

机构：

[1] Univ Basel, Inst Physiol, CH-4056 Basel, Switzerland

[2] Univ Basel, Inst Anat, Dept Clin Biol Sci, CH-4056 Basel, Switzerland

[3] Univ Basel, Div Pharmacol, Biozentrum, CH-4056 Basel, Switzerland

[4] Univ Calif Davis, Ctr Comparat Med, Sch Vet Med, Davis, CA 95616 USA

[5] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

[6] Scripps Res Inst, Inst Childhood & Neglected Dis, La Jolla, CA 92037 USA

来源：

SCIENCE | 2005年 / 308卷 / 5730期

关键词：

D O I：

10.1126/science.1108258

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.

引用

页码：1920 / 1923

页数：4

共 29 条

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BEZAKOVA G, UNPUB

[2] The transcription factor Sox10 is a key regulator of peripheral glial development [J].