Nitric oxide neurotoxicity in neurodegenerative diseases

被引：129

作者：

Boje, KMK ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Pharmaceut Sci, Sch Pharm & Pharmaceut Sci, Buffalo, NY 14260 USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2004年 / 9卷

关键词：

nitric oxide; blood brain barrier; neuroinflammation; neurodegenerative diseases; Acquired Immune Deficiency Syndrome (AIDS) dementia complex; HIV-Associated Dementia; amyotrophic lateral sclerosis; Alzheimer's Disease; Huntington's Disease; multiple sclerosis; Parkinson's Disease; review;

D O I：

10.2741/1268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (nitrogen monoxide; NO) is a simple molecule with diverse biological functions. NO and related reactive nitrogen oxide species (RNOS) mediate intricate physiological and pathophysiological effects in the central nervous system. Depending on environmental conditions, NO and RNOS can initiate and mediate neuroprotection or neurotoxicity either exclusively or synergistically with other effectors. The focus of this review is limited to the neuroprotectant/neurotoxic role of NO in Acquired Immune Deficiency Syndrome (AIDS) Dementia Complex (aka HIV-Associated Dementia; HAD) Amyotrophic Lateral Sclerosis (aka Lou Gehrig's Disease), Alzheimer's Disease, Huntington's Disease, Multiple Sclerosis and Parkinson's Disease. This review will shed light on the question: "How important is NO in neurodegenerative diseases?"

引用

页码：763 / 776

页数：14

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