Asymmetric synthesis of β-hydroxy esters having three consecutive chiral centers with a reductase from bakers' yeast

被引：13

作者：

Kawai, Y ^{[1
]}

Hida, K

Dao, DH

Ohno, A

机构：

[1] Kyoto Univ, Chem Res Inst, Kyoto 6110011, Japan

[2] Niigata Univ, Grad Sch Sci & Technol, Course Fundamental Studies & Energy Technol, Niigata 9502181, Japan

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 50期

关键词：

enzymes and enzyme reactions; asymmetric synthesis; hydroxy acids and derivatives;

D O I：

10.1016/S0040-4039(98)02102-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric synthesis of methyl 2-alkyl-3-hydroxybutanoate having three consecutive chiral centers with a reductase from bakers' yeast has been investigated. When the enzyme is employed in the reduction of a beta-keto ester substituted by a secondary alkyl group at alpha-position, the reaction affords the corresponding beta-hydroxy ester in excellent stereoselectivity. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：9219 / 9222

页数：4

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