Flavonoid, iridoid, and lignan glycosides from Putoria calabrica

被引:37
作者
Çalis, I [1 ]
Heilmann, J
Tasdemir, D
Linden, A
Ireland, CM
Sticher, O
机构
[1] Hacettepe Univ, Fac Pharm, Dept Pharmacognosy, TR-06100 Ankara, Turkey
[2] Swiss Fed Inst Technol, Inst Pharmaceut Sci, Dept Appl BioSci, CH-8057 Zurich, Switzerland
[3] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA
[4] Univ Zurich, Inst Organ Chem, CH-8057 Zurich, Switzerland
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 07期
关键词
D O I
10.1021/np000614h
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
From the aerial parts of Putoria calabrica, two new flavonol triglycosides were isolated and their structures were elucidated as quercetin-3-O-[alpha -L-rhamnopyranosyl-(1 -->2)-alpha -L-arabinopyranosidel-7-O-beta -D-glucopyranoside (1, calabricoside A) and quercetin-3-O-[4"'-O-caffeoyl-alpha -L-rhamnopyranosyl-(1 -->2)-alpha -L-arabinopyranosidel-7-0-,8-D-glucopyranoside (2, calabricoside B). Additionally, seven iridoid and three lignan glycosides were isolated and characterized. Radical scavenging activities of all compounds were determined by quantifying their effects on luminol-enhanced chemiluminescence in formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated human polymorphonuclear neutrophils (PMNs). Calabricoside A and B showed strong radical scavenging activity with IC50 values of 0.25 and 0.3 muM, respectively.
引用
收藏
页码:961 / 964
页数:4
相关论文
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