Proton Magnetic Resonance Spectroscopy and MRI Reveal No Evidence for Brain Mitochondrial Dysfunction in Children with Autism Spectrum Disorder

被引：23

作者：

Corrigan, Neva M. ^{[1
]}

Shaw, Dennis. W. W. ^{[1
,2
]}

Richards, Todd L. ^{[1
]}

Estes, Annette M. ^{[4
,5
]}

Friedman, Seth D. ^{[2
]}

Petropoulos, Helen ^{[1
]}

Artru, Alan A. ^{[3
]}

Dager, Stephen R. ^{[1
,4
,6
]}

机构：

[1] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[2] Seattle Childrens Hosp, Seattle, WA USA

[3] Univ Washington, Dept Anesthesiol, Seattle, WA 98195 USA

[4] Univ Washington, Autism Ctr, Seattle, WA 98195 USA

[5] Univ Washington, Dept Speech & Hearing Sci, Seattle, WA 98195 USA

[6] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2012年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Autism; Developmental disorders; MRS; MRI; Mitochondrial disorders; Brain metabolism; Lactate; YOUNG-CHILDREN; DIAGNOSTIC EVALUATION; METABOLIC-RESPONSE; PANIC DISORDER; HYPERVENTILATION; ABNORMALITIES; DNA; INVOLVEMENT; DISEASE; GRAY;

D O I：

10.1007/s10803-011-1216-y

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ((HMRS)-H-1) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3-4, 6-7 and 9-10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. (HMRS)-H-1 and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship.

引用

页码：105 / 115

页数：11

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