Pros and cons of the use of antihistamines in managing allergic rhinitis

Histamine H-1-receptor antagonists are generally considered first-line therapy for the management of allergic rhinitis, Other than histamine antagonism, several of the second-generation antihistamines have also shown inhibitory effects on chemical mediators of inflammation such as leukotrienes, prostaglandins, and kinins, This article reviews the pharmacology, clinical use, and side effect profiles of the commonly used H-1-receptor antagonists.