Catalytic asymmetric reductive Michael cyclization

被引：337

作者：

Yang, JW ^{[1
]}

Fonseca, MTH ^{[1
]}

List, B ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 43期

关键词：

D O I：

10.1021/ja055735o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and chemo-, regio-, diastereo-, and enantioselective organocatalytic tandem conjugate reduction-Michael cyclization of enal enones has been developed. Accordingly, treating the enal enone with a Hantzsch dihydropyridine in the presence of a catalytic amount of an imidazolidinone organocatalyst provides cyclic keto aldehydes in high yields and enantiomeric excesses. The reaction works well with aliphatic and aromatic substrates in the synthesis of five- and six-membered carbacyclic derivatives. Copyright © 2005 American Chemical Society.

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页码：15036 / 15037

页数：2

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