Water-soluble tripeptide Aβ(9-11) forms amyloid-like fibrils and exhibits neurotoxicity

被引：29

作者：

Naskar, Jishu ^{[2
]}

Drew, Michael G. B. ^{[3
]}

Deb, Ishani ^{[4
]}

Das, Sumantra ^{[4
]}

Banerjee, Arindam ^{[1
,2
]}

机构：

[1] Indian Inst Chem Biol, Div Chem, Kolkata 700032, W Bengal, India

[2] Indian Assoc Cultivat Sci, Dept Biol Chem, Kolkata 700032, W Bengal, India

[3] Univ Reading, Sch Chem, Reading RG6 6AD, Berks, England

[4] Indian Inst Chem Biol, Cell Biol & Physiol Div, Kolkata 700032, W Bengal, India

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 13期

关键词：

D O I：

10.1021/ol8007217

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A water-soluble, hydrophilic tripeptide GYE, having sequence identity with the N-terminal segment of amyloid peptides A,beta(9-11), upon self-association exhibits amyloid-like fibrils and significant neurotoxicity towards the Neuro2A cell line. However, the tripeptides GFE and GWE, in which the centrally located tyrosine residue has been replaced by phenylalanine or tryptophan, fail to show amyloidogenic behavior and exhibit little or no neurotoxicity.

引用

页码：2625 / 2628

页数：4

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