Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa

被引：78

作者：

Espino, Javier ^{[1
]}

Bejarano, Ignacio ^{[1
]}

Ortiz, Agueda ^{[2
]}

Lozano, Graciela M. ^{[2
]}

Garcia, Juan F. ^{[2
]}

Pariente, Jose A. ^{[1
]}

Rodriguez, Ana B. ^{[1
]}

机构：

[1] Univ Extremadura, Dept Physiol, Fac Sci, E-06071 Badajoz, Spain

[2] Extremadura Ctr Human Assisted Reprod, Badajoz, Spain

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 05期

关键词：

HYDROGEN-PEROXIDE; REACTIVE OXYGEN; SPERM; ACTIVATION; STRESS; PROGESTERONE;

D O I：

10.1016/j.fertnstert.2009.12.082

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

It is assumed somatic cells can die in the apoptotic, the autophagic, or the necrotic way; however, the mechanisms of sperm death are not clear. Here, ejaculated human spermatozoa were evaluated for apoptosis and reactive oxygen species production in the absence or presence of melatonin, and we concluded that melatonin reverses sperm apoptosis due to its free radical scavenging actions. (Fertil Steril (R) 2010;94:1915-7. (C) 2010 by American Society for Reproductive Medicine.)

引用

页码：1915 / 1917

页数：3

共 17 条

[1] RELATIONSHIP OF SPERM PARAMETERS WITH LEVELS OF REACTIVE OXYGEN SPECIES IN SEMEN SPECIMENS [J].

AGARWAL, A ;

IKEMOTO, I ;

LOUGHLIN, KR .

JOURNAL OF UROLOGY, 1994, 152 (01) :107-110

[2] Caspase 3 activation in human spermatozoa in response to hydrogen peroxide and progesterone [J].

Bejarano, Ignacio ;

Lozano, Graciela M. ;

Ortiz, Agueda ;

Garcia, Juan F. ;

Paredes, Sergio D. ;

Rodriguez, Ana B. ;

Pariente, Jose A. .

FERTILITY AND STERILITY, 2008, 90 :1340-1347

[3] Calcium, ATP, and ROS: a mitochondrial love-hate triangle [J].

Brookes, PS ;

Yoon, YS ;

Robotham, JL ;

Anders, MW ;

Sheu, SS .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 287 (04) :C817-C833

[4] Apoptosis - the calcium connection [J].

Demaurex, N ;

Distelhorst, C .

SCIENCE, 2003, 300 (5616) :65-67

[5] Reduced levels of intracellular calcium releasing in spermatozoa from asthenozoospermic patients [J].

Espino, Javier ;

Mediero, Matias ;

Lozano, Graciela M. ;

Bejarano, Ignacio ;

Ortiz, Agueda ;

Garcia, Juan F. ;

Pariente, Jose A. ;

Rodriguez, Ana B. .

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2009, 7

[6] Melatonin-enhanced hyperactivation of hamster sperm [J].

Fujinoki, Masakatsu .

REPRODUCTION, 2008, 136 (05) :533-541

[7] Caspase activation in human spermatozoa in response to physiological and pathological stimuli [J].

Grunewald, S ;

Paasch, U ;

Said, TM ;

Sharma, RK ;

Glander, HJ ;

Agarwal, A .

FERTILITY AND STERILITY, 2005, 83 :1106-1112

[8] Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines [J].

Hardeland, Ruediger ;

Tan, Dun-Xian ;

Reiter, Russel J. .

JOURNAL OF PINEAL RESEARCH, 2009, 47 (02) :109-126

[9] EFFECTS OF INDOLEAMINES ON SPERM MOTILITY INVITRO [J].

IREZ, TO ;

SENOL, H ;

ALAGOZ, M ;

BASMACIOGULLARI, C ;

TURAN, F ;

KURU, D ;

ERTUNGEALP, E .

HUMAN REPRODUCTION, 1992, 7 (07) :987-990

[10] Melatonin protects against common deletion of mitochondrial DNA-augmented mitochondrial oxidative stress and apoptosis [J].

Jou, Mei-Jie ;

Peng, Tsung-I ;

Yu, Pai-Zu ;

Jou, Shuo-Bin ;

Reiter, Russel J. ;

Chen, Jin-Yi ;

Wu, Hong-Yueh ;

Chen, Chih-Chun ;

Hsu, Lee-Fen .

JOURNAL OF PINEAL RESEARCH, 2007, 43 (04) :389-403

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