Lasonolide A: Synthesis of A and B rings via a cycloetherification strategy

被引：20

作者：

Hart, DJ ^{[1
]}

Patterson, S ^{[1
]}

Unch, JP ^{[1
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

来源：

SYNLETT | 2003年 / 09期

关键词：

tetrahydropyran; cycloetherification; phenylselenenyl chloride; lasonolide A; macrolide;

D O I：

10.1055/s-2003-40323

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of tetrahydropyrans ent-2 and ent-3, substructures of the A and B rings of the enantiomer of lasonolide A (1), are described. The syntheses of ent-2 and ent-3 feature highly stereo-selective cycloetherification reactions of bis-homoallylic alcohols 7 and 8.

引用

页码：1334 / 1338

页数：5

共 36 条

[31] HIGHLY DIASTEREOSELECTIVE ALKYLATION ONTO 4-ACETOXY-2-AZETIDINONES EMPLOYING TIN(II) ENOLATES OF C4-CHIRAL 3-ACYL-1,3-THIAZOLIDINE-2-THIONES [J].